LMDE is Debian based whereas the regular Mint is Ubuntu-based, which probably explains issues you’ve experienced.

All the ones I’ve used so far are able to use the GPU but it has to be enabled in the app settings. I mostly use LM Studio and it flies on my nvidia 3060. Doesn’t seem to have options for AMD GPUs though, unless I’m mistaken.

Mill St brewery was bought by Molson (or other industrial piss maker) a few years back. Total boycott on my part.